As fantasy football managers set their lineups this week, knowing which players are active or inactive is critical to securing your victory. With Week 12 upon us, we've compiled the latest updates on player statuses to help you navigate your fantasy decisions. Here’s the rundown of who is not playing, who’s a go, and how these decisions could impact your rosters.

4 p.m. ET Games

- **Josh Reynolds, WR, DEN:** **OUT/IR** - Reynolds' hand injury has sidelined him, but there’s hope he might return next week. With him out, Devaughn Vele and Lil'Jordan Humphrey maintain their minimal fantasy appeal.

- **Alexander Mattison, RB, LV:** **Inactive** - An ankle injury will keep Mattison on the sidelines. Expect a mix of Ameer Abdullah and Zamir White to shoulder the load at running back for Las Vegas.

- **Noah Fant, TE, SEA:** **Inactive** - Fant’s groin issue leaves Seattle desperate at tight end, with limited options behind him.

- **Tyler Lockett, WR, SEA:** **Active** - Lockett managed to make it through the injury report late in the week and will suit up. Stalwart Laviska Shenault Jr. is inactive.

- **Brock Purdy, QB, SF:** **OUT** - A shoulder injury for Purdy means Brandon Allen will step in as the starter. Lower expectations for all 49ers receivers in his absence.

Sunday Night Game

- **DeVonta Smith, WR, PHI:** **OUT** - The hamstring issue for Smith means Jahan Dotson will have a bigger role to complement A.J. Brown.

1 p.m. ET Games

- **Eddy Pineiro, K, CAR:** **Active** - Despite his knee injury sustained during a celebratory moment, Pineiro is good to go.

- **Jonathon Brooks, RB, CAR:** **Active** - Making his debut, Brooks could cut into Chuba Hubbard's workload after Miles Sanders was ruled out due to an ankle injury.

- **Adam Thielen, WR, CAR:** **Active** - Thielen has been activated from IR but might have limitations after being limited in practice throughout the week. Monitor his snap count.

- **D'Andre Swift, RB, CHI:** **Active** - Swift's groin injury appears to be cleared, but how carries will be split with Roschon Johnson remains uncertain.

- **Keenan Allen, WR, CHI:** **Active** - Despite recent ankle troubles, Allen is in, but should he falter, expect Rome Odunze and DJ Moore to step up.

- **Jake Ferguson, TE, DAL:** **OUT** - A concussion sidelines Ferguson; feel free to turn to Luke Schoonmaker if you're in a tight spot.

- **Brandin Cooks, WR, DAL:** **OUT/IR** - Cooks wasn’t activated from IR, leaving CeeDee Lamb as the only receiver in Dallas worthy of fantasy attention.

- **Isiah Pacheco, RB, KC:** **OUT/IR** - The Chiefs are holding off on activating Pacheco, which means Kareem Hunt will take the bulk of carries against a tough opponent.

- **Josh Oliver, TE, MIN:** **OUT** - His wrist injury won’t affect fantasy rosters significantly, but it does mean T.J. Hockenson will see extended playtime.

- **Malik Nabers, WR, NYG:** **Active** - Nabers is set to play, joining Darius Slayton, but with Tommy DeVito now leading the way, be cautious in trusting this wide receiver duo.

- **Mike Evans, WR, TB:** **Active** - Evans was always on track to play, and barring any pre-game hiccups, fantasy owners can rely on him.

- **Tyjae Spears, RB, TEN:** **OUT** - Spears’ concussion keeps him out, allowing Tony Pollard to continue dominating touches in the Titans' backfield.

Conclusion

As the clock ticks down to kickoff, it's crucial to keep an eye on the injury report to make informed fantasy choices. Check back frequently for updates as teams finalize their rosters! Make sure to adjust your lineups accordingly to maximize your chances of winning big this week. Don't let injuries surprise you—plan ahead and dominate Week 12!