As fantasy football managers grapple with a wave of injuries, having reliable and up-to-date rankings is crucial now more than ever. Recently, star wide receiver Nico Collins fell victim to a hamstring injury, landing him on injured reserve, and throwing his fantasy owners into a frenzy. His absence shifts the spotlight to teammates Stefon Diggs and Tank Dell, but it could also spell trouble for quarterback C.J. Stroud and the Houston Texans' overall performance. So, how can you strategically replace Collins in your lineup for Week 6 and beyond? To help you make those tough start-sit decisions and maximize your potential, look no further than the Week 6 Fantasy football rankings powered by an efficient computer model from SportsLine, which has outperformed human analysts time and time again. Last season, the model not only identified key breakout players but also assisted in guiding fantasy managers toward their league victories.

Top Week 6 Fantasy Football QB Rankings: The Aces for Your Lineup

1. **Lamar Jackson, Baltimore Ravens**: Coming off a sensational week with four touchdowns and 348 passing yards against the Bengals, Jackson rises as the top fantasy QB. With his high mobility and explosive playmaking ability, he remains a top asset. 2. **Jalen Hurts, Philadelphia Eagles**: After a bye week, Hurts faces a Browns defense that has struggled this season, dropping from first to mediocre rankings. Expect big plays from him as he navigates a recovery week against Cleveland. 3. **Jordan Love, Green Bay Packers**: After proving his mettle against the Rams, Love manages a favorable matchup against the Cardinals, who provide weak pass defense. He could easily rack up points for fantasy owners looking for a solid QB play.

Top Week 6 Fantasy Football RB Rankings: Game-Changers to Consider

1. **Saquon Barkley, Philadelphia Eagles**: Barkley looks rejuvenated after moving from the Giants, with impressive stats this year and an opportunity to excel against a Browns defense that has struggled against the run. 2. **Derrick Henry, Baltimore Ravens**: Dominating the league in yardage and touchdowns, Henry thrives with Jackson in the pocket, opening up lanes that make him a must-start. 3. **Jahmyr Gibbs, Detroit Lions**: Gibbs has become a vital part of the Lions offense with consistent touches. Up against a Dallas defense that falters against the run, he's a solid pick for those looking to capitalize.

Top Week 6 Fantasy Football WR Rankings: Unsung Heroes Set to Shine

1. **CeeDee Lamb, Dallas Cowboys**: While Lamb’s 2024 stats may seem modest, his consistent involvement in the Cowboys' offense, combined with a favorable matchup against a 27th-ranked Lions pass defense, makes him an ideal start. 2. **Jayden Reed, Green Bay Packers**: While he may seem underutilized, Reed is quickly becoming a reliable target for Love. His versatility and scoring potential make him a sneaky good option. 3. **Ja'Marr Chase, Cincinnati Bengals**: After a slow start, Chase has emerged as a scoring machine, leading the high-powered Bengals offense. Expect another remarkable performance against a challenging opponent.

Top Week 6 Fantasy Football TE Rankings: Impact Players You Can’t Ignore

1. **George Kittle, San Francisco 49ers**: With a season-high target count last week, Kittle continues to establish himself as a key player. If he can maintain momentum, look for him to capitalize on the Seahawks' defensive struggles. 2. **Brock Bowers, Las Vegas Raiders**: As a standout rookie, Bowers is making waves, having a breakout performance recently. With his dynamic ability, he’s worth considering for your roster. 3. **Dallas Goedert, Philadelphia Eagles**: Even with competition in the Eagles’ receiving corps, Goedert has shown he can produce. His recent form makes him a valuable asset against the Browns.

Top Week 6 Fantasy Football Defense Rankings: Shut-Down Squads

1. **Texans D/ST**: Despite mixed results in points allowed, the Texans boast a solid matchup against low-scoring Patriots. This is an opportunity to pounce on a struggling offense. 2. **Bills D/ST**: The Bills are looking to rebound against a jet-lagged Jets team, which has been inconsistent this season. This matchup could favor Buffalo's aggressive defense. 3. **Colts D/ST**: The Colts may have had their struggles, but they face a Titans team that is prone to turnovers. Expect big plays and potential pick-sixes.

With so much volatility in player performances, make sure to utilize comprehensive rankings from SportsLine. They’ve pinpointed hidden gems within the top ten at running back that could give you a decisive edge in your league. Don’t miss out—get your strategies in place and dominate your fantasy matchups this week!