A Tough Blow for Liverpool

The Reds will head into the game without their captain Andy Robertson, who is serving a one-match suspension following his red card in the recent 2-2 draw against Fulham. This absence will make Slot’s defensive choices limited as they look to maintain a strong backline.

In more encouraging news, Liverpool welcomes back midfielder Alexis Mac Allister after his own suspension, as well as the return of Diogo Jota, who made a comeback from injury with a goal in the last match. Additionally, Federico Chiesa is also available, allowing Slot to rotate his squad effectively as the busy holiday fixtures approach.

Potential Changes in Goal and Defense

Caoimhin Kelleher may reclaim his position in goal, replacing Alisson Becker, who has regained his starting spot following injury. However, the defensive lineup poses a challenge, with Ibrahima Konate, Conor Bradley, and Kostas Tsimikas out of action. Joe Gomez is expected to shift to left-back to cover for Robertson, though Trent Alexander-Arnold could also be utilized in that position given his recent experience playing there for the national team.

For a more adventurous approach, James Norris, who has yet to see action since January 2022, could be tapped as an alternative at left-back. Meanwhile, 18-year-old Amara Nallo could be handed his first senior debut in central defense, signaling Slot's willingness to infuse youthful energy into the lineup.

Midfield Dynamics with Mac Allister's Return

Mac Allister's return to the midfield will be pivotal, but where he fits best remains a question. Ryan Gravenberch is likely to be rested, opening the door for Wataru Endo to step in as the defensive anchor. Tyler Morton might partner with Mac Allister, potentially seeing the Argentine deployed in a more advanced playmaking role.

If Slot chooses to deploy Mac Allister deeper, young talent Harvey Elliott could receive his first start of the season in an attacking midfield role. The competition is fierce, with Curtis Jones and Dominik Szoboszlai also vying for spots in the starting XI, alongside budding star Trey Nyoni.

A Revamped Attack Awaits

In the forward line, Darwin Nunez is expected to lead the attack, especially after providing an assist against Fulham. Jota could return on the left wing, where he thrived before his injury layoff. As for Chiesa, he may start on the bench as the coaching staff manages his match fitness after an extended absence.

Resting star Mohamed Salah seems probable, paving the way for Elliott or even Nunez to exploit the right flank. All eyes will be on Slot’s strategy in what promises to be an exciting encounter against Southampton, as Liverpool looks to advance in the League Cup and potentially start their path to silverware this season.

As the Reds prepare for this critical match, fans are left speculating how Slot’s decisions could shape the future of this illustrious club, especially with the holiday fixtures on the horizon and the need for squad depth becoming ever more pressing.