Introduction

Early embryonic development is a remarkable process where the initial growth is entirely governed by the materials supplied by the mother. This phase continues until the embryo's own genetic material comes into play, a critical turning point known as zygotic genome activation (ZGA). Recent research led by Chinese scientists has unveiled a significant molecular mechanism behind how totipotent chromatin is formed and how ZGA is meticulously regulated in early Drosophila embryos.

Published Research

Published in the Proceedings of the National Academy of Sciences on November 14, the study titled "HIRA and dPCIF1 coordinately establish totipotent chromatin and control orderly ZGA in Drosophila embryos" sheds light on these processes.

Zygotic Genome Activation (ZGA)