Even after five years since the emergence of COVID-19 as a global pandemic, new variants of the SARS-CoV-2 virus continue to appear, keeping health officials alert. The latest variant making headlines is LP.8.1, which has been on the rise across several regions, including Australia and the United Kingdom. This variant currently constitutes approximately one in five COVID-19 cases in New South Wales and has become alarming in the UK, where it represents at least 60% of cases.

What Exactly is LP.8.1?

First detected in July 2024, LP.8.1 is an offshoot of the Omicron family, specifically stemming from the subvariant KP.1.1.3, which in turn descends from JN.1. This lineage has already contributed to significant waves of infections globally in late 2023 and early 2024. The World Health Organization (WHO) has classified LP.8.1 as a variant under monitoring since January 2025 due to its rapid spread and notable genetic mutations that may enhance transmissibility.

LP.8.1 features six significant mutations in its spike protein—the key component that enables the virus to attach to human cells. A particular mutation known as V445R is believed to increase the virus's capability to invade human lung cells and spread more effectively compared to other variants.

Should We Be Worried?

Fortunately, despite LP.8.1’s spread, the symptoms have not been reported as more severe than those caused by existing strains. The WHO has assessed the additional public health risk of LP.8.1 as low, and as it stands, this variant remains in the monitoring category rather than being classified as a variant of interest or concern.

However, it’s crucial to note that rising case numbers are still a substantial public health threat. Recent statistics reveal nearly 45,000 new COVID cases in Australia alone this year, with around 260 individuals currently hospitalized. The actual figures could be much higher, as many people opt not to test or report their infections.

The Situation on the Ground

In New South Wales, LP.8.1 has become one of the most prevalent strains, ranked third after XEC and KP.3. This trend reflects a consistent increase over recent months, a pattern that is likely to persist across other states and territories. Surveillance data indicates a surge in reported LP.8.1 sequences, from about 3% at the end of 2024 to an alarming 38% by mid-March.

Globally, LP.8.1 has also gained significant prevalence, responsible for over 55% of cases in the United States and around 60% in the UK, raising concerns among scientists about the potential for a fresh wave of infections.

Are Vaccines Still Effective?

Despite the emergence of LP.8.1, existing COVID vaccines, including the latest JN.1 formulations, are still expected to provide robust protection against both symptomatic and severe cases linked to this variant. Nevertheless, the WHO will continue to monitor the variant's activity and any possible ability to bypass immunity developed through vaccination.

Conclusion: Stay Informed and Cautious

The rise of the LP.8.1 variant serves as a stark reminder that COVID-19 remains a critical health issue. As the world navigates this evolving pandemic landscape, staying informed about new variants and adhering to public health guidelines is essential. Experts warn that complacency can be perilous; we must remain vigilant as LP.8.1 continues to spread.