Injury Concerns Loom as 49ers Prepare for Critical Showdown Against Bills

In a crucial Thanksgiving Day practice, the San Francisco 49ers faced significant injury challenges as quarterback Brock Purdy remained limited, casting uncertainty on his availability for the upcoming game against the Buffalo Bills. Purdy, who missed the 49ers' disappointing 38-10 loss to the Green Bay Packers last Sunday due to a shoulder injury, had been experiencing difficulties with his throwing arm since the previous week's defeat against the Seattle Seahawks.

In Purdy's absence, Brandon Allen took the helm as the starting quarterback against Green Bay, but the team suffered under his leadership. Now, with a 5-6 record, the 49ers are looking to turn things around against the formidable Bills, who stand at 9-2 and boast a six-game winning streak before their recent bye week.

The injury report did not look promising for the 49ers, as several key players were sidelined during Thursday's practice. Defensive end Nick Bosa (oblique, hip), left tackle Trent Williams (ankle), guard Aaron Banks (concussion), cornerback Deommodore Lenoir (knee), defensive tackle Jordan Elliott (concussion), and linebacker Demetrius Flannigan-Fowles were all unable to participate.

Notably, practice was closed off to the media, leaving the extent of Purdy's workload unreported. Coach Kyle Shanahan shared some optimism, stating that after a restful weekend of rehabilitation in Green Bay, Purdy started throwing again on Monday without experiencing pain. Despite this progress, he was only seen attempting a couple of short passes during Wednesday's warm-up, leading to concerns about his readiness for the upcoming matchup.

On a brighter note, running back Christian McCaffrey participated fully in practice after taking Wednesday off for rest. However, the injury report expanded as wide receiver Chris Conley was added with a knee issue, limiting his participation, along with linebacker Dre Greenlaw (Achilles), defensive tackle Kevin Givens (groin), and guard Dominick Puni (shoulder).

Meanwhile, cornerback Charvarius Ward returned to practice full-speed after taking a three-game leave for bereavement. Return specialist Jacob Cowing also returned to full participation after clearing concussion protocols.

Across the field, the Bills are dealing with their own injury concerns. Tight end Dalton Kincaid missed his second straight practice due to a knee injury, while offensive tackle Spencer Brown returned as a full participant after being limited the day before. Wide receiver Keon Coleman continued to be limited owing to a wrist injury.

As both teams gear up for this highly anticipated clash, fans are left wondering: Can the 49ers overcome their injury woes and stage an upset against the well-rested Bills? Tune in this Sunday to find out!